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(OBJECTIVE: To investigate disparities in MS presentation, management, and disability progression across different ethnic and socioeconomic groups using real-world data from the UK MS Register.) /E (OBJECTIVE: To investigate disparities in MS presentation, management, and disability progression across different ethnic and socioeconomic groups using real-world data from the UK MS Register.) /Pg 7 0 R /K [1] >> endobj 25 0 obj << /Type /StructElem /S /H3 /T (RESULTS Patient Characteristics) /E (RESULTS Patient Characteristics) /Pg 7 0 R /K [2] >> endobj 26 0 obj << /Type /StructElem /S /H4 /P 71 0 R /T (The study included patients from African \(n=71\), Caribbean \(n=227\), South Asian \(n=277\), and Other \(n=226\) backgrounds.) /E (The study included patients from African \(n=71\), Caribbean \(n=227\), South Asian \(n=277\), and Other \(n=226\) backgrounds.) /Pg 7 0 R /K [3] >> endobj 27 0 obj << /Type /StructElem /S /H3 /T (Disparities in MS Management) /E (Disparities in MS Management) /Pg 7 0 R /K [4] >> endobj 28 0 obj << /Type /StructElem /S /H4 /P 72 0 R /T (Positive Finding: Ethnic Minority patients had significantly higher DMT uptake than the Ethnic Majority \(49.8% vs 38.6%, p<0.001\) and were more likely to be on highly active therapies.) /E (Positive Finding: Ethnic Minority patients had significantly higher DMT uptake than the Ethnic Majority \(49.8% vs 38.6%, p<0.001\) and were more likely to be on highly active therapies.) /Pg 7 0 R /K [5] >> endobj 29 0 obj << /Type /StructElem /S /H4 /P 73 0 R /T (Challenge: Patients of African ethnicity experienced the longest mean delay to diagnosis \(4.23 years\), a significant disparity \(p=0.0199\).) /E (Challenge: Patients of African ethnicity experienced the longest mean delay to diagnosis \(4.23 years\), a significant disparity \(p=0.0199\).) /Pg 7 0 R /K [6] >> endobj 30 0 obj << /Type /StructElem /S /Figure /P 18 0 R /Pg 7 0 R /K [28] >> endobj 31 0 obj << /Type /StructElem /S /H2 /T (METHODS) /E (METHODS) /Pg 7 0 R /K [7] >> endobj 32 0 obj << /Type /StructElem /S /H4 /P 74 0 R /T (Data Source: Anonymised data from the UK MS Register, a prospective registry of people with MS.) /E (Data Source: Anonymised data from the UK MS Register, a prospective registry of people with MS.) /Pg 7 0 R /K [8] >> endobj 33 0 obj << /Type /StructElem /S /H4 /P 75 0 R /T (Study Population: Patients with a confirmed MS diagnosis identifying as African, Caribbean, South Asian, or Other, compared with the Ethnic Majority population for treatment patterns.) /E (Study Population: Patients with a confirmed MS diagnosis identifying as African, Caribbean, South Asian, or Other, compared with the Ethnic Majority population for treatment patterns.) /Pg 7 0 R /K [9] >> endobj 34 0 obj << /Type /StructElem /S /H4 /P 76 0 R /T (Variables: Socioeconomic: Education Level, Employment Status.) /E (Variables: Socioeconomic: Education Level, Employment Status.) /Pg 7 0 R /K [10] >> endobj 35 0 obj << /Type /StructElem /S /H4 /P 77 0 R /T (Clinical: MS Type, Disease Progression.) /E (Clinical: MS Type, Disease Progression.) /Pg 7 0 R /K [11] >> endobj 36 0 obj << /Type /StructElem /S /H4 /P 78 0 R /T (Management: DMT Use, Time to DMT Start.) /E (Management: DMT Use, Time to DMT Start.) /Pg 7 0 R /K [12] >> endobj 37 0 obj << /Type /StructElem /S /H4 /P 79 0 R /T (Statistical Analysis:) /E (Statistical Analysis:) /Pg 7 0 R /K [13] >> endobj 38 0 obj << /Type /StructElem /S /H4 /P 80 0 R /T (Descriptive statistics were compared using Chi-square and ANOVA tests) /E (Descriptive statistics were compared using Chi-square and ANOVA tests) /Pg 7 0 R /K [14] >> endobj 39 0 obj << /Type /StructElem /S /H4 /P 81 0 R /T (Demographics: Ethnicity, Age at Diagnosis, Gender.) /E (Demographics: Ethnicity, Age at Diagnosis, Gender.) /Pg 7 0 R /K [15] >> endobj 40 0 obj << /Type /StructElem /S /H4 /P 82 0 R /T (Time to disability progression was analysed using univariate and multivariate Cox proportional hazards models.) /E (Time to disability progression was analysed using univariate and multivariate Cox proportional hazards models.) /Pg 7 0 R /K [16] >> endobj 41 0 obj << /Type /StructElem /S /H4 /P 83 0 R /T (P-value < 0.05 was considered statistically significant.) /E (P-value < 0.05 was considered statistically significant.) /Pg 7 0 R /K [17] >> endobj 42 0 obj << /Type /StructElem /S /Figure /P 18 0 R /Pg 7 0 R /K [29] >> endobj 43 0 obj << /Type /StructElem /S /H2 /T (CONCLUSION) /E (CONCLUSION) /Pg 7 0 R /K [18] >> endobj 44 0 obj << /Type /StructElem /S /H4 /P 84 0 R /T (In the UK, ethnic minority patients with MS demonstrate a higher uptake of disease-modifying therapies compared to the majority population, a key positive finding.) /E (In the UK, ethnic minority patients with MS demonstrate a higher uptake of disease-modifying therapies compared to the majority population, a key positive finding.) /Pg 7 0 R /K [19] >> endobj 45 0 obj << /Type /StructElem /S /H4 /P 85 0 R /T (However, disparities in timeliness of diagnosis persist for some groups.) /E (However, disparities in timeliness of diagnosis persist for some groups.) /Pg 7 0 R /K [20] >> endobj 46 0 obj << /Type /StructElem /S /H4 /P 86 0 R /T <546865207072696D6172792064726976657273206F6620666173746572206469736162696C6974792070726F6772657373696F6E2061726520736F63696F65636F6E6F6D696320666163746F7273846E6F7461626C79206C6F77657220656475636174696F6E20616E6420756E656D706C6F796D656E7484726174686572207468616E206574686E696369747920697473656C662E> /E <546865207072696D6172792064726976657273206F6620666173746572206469736162696C6974792070726F6772657373696F6E2061726520736F63696F65636F6E6F6D696320666163746F7273846E6F7461626C79206C6F77657220656475636174696F6E20616E6420756E656D706C6F796D656E7484726174686572207468616E206574686E696369747920697473656C662E> /Pg 7 0 R /K [21] >> endobj 47 0 obj << /Type /StructElem /S /H4 /P 87 0 R /T (These findings suggest that strategies to mitigate health inequality in MS should focus on addressing socioeconomic barriers to improve long-term outcomes for all patients.) /E (These findings suggest that strategies to mitigate health inequality in MS should focus on addressing socioeconomic barriers to improve long-term outcomes for all patients.) /Pg 7 0 R /K [22] >> endobj 48 0 obj << /Type /StructElem /S /H4 /T (Acknowledgements: I thank all participants of the UK MS Register and the wonderful team at UK MS Register Swansea University.) /E (Acknowledgements: I thank all participants of the UK MS Register and the wonderful team at UK MS Register Swansea University.) /Pg 7 0 R /K [23] >> endobj 49 0 obj << /Type /StructElem /S /P /E 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